LYSOSOMAL ACID LIPASE A MODULATES LEUKEMIA STEM CELL RESPONSE TO VENETOCLAX/TYROSINE KINASE INHIBITOR COMBINATION THERAPY IN BLAST PHASE CHRONIC MYELOID LEUKEMIA

The treatment of blast phase chronic myeloid leukemia (bpCML) remains a challenge due at least in part to drug resistance of leukemia stem cells (LSCs).Recent clinical evidence suggests that the BCL-2 inhibitor venetoclax in combination with ABL-targeting tyrosine Day cream kinase inhibitors (TKIs) can eradicate bpCML LSCs.In this report, we employ

Abstract The current condition of the Covid-19 pandemic that Indonesia is currently experiencing requires people to avoid gatherings and maintain social distancing.With this condition, how is the role of political parties in political education during the Covid-19 pandemic (Study on the Prosperous Justice Party at the DPC PKS, Kalidoni District, Pa

This article aims to provide an in-depth research into the importance of English silver, the oldest of the traditional crafts that served the social, aesthetic and functional needs of English nobility and aristocracy for centuries, in the British Collections market, economy, design and culture, in general, in the late eighteenth and early nineteent

Many species execute ballistic escape reactions to avoid imminent danger.Despite fast reaction times, responses are often highly regulated, reflecting a trade-off between costly motor actions and perceived threat level.However, how sensory cues are NMN Flavonoid Complex integrated within premotor escape circuits remains poorly understood.Here, we s